Research - Laboratory/Non-Laboratory, Staff/Administrative
Do you want to fight malaria, coronavirus, and HIV with science? Are you interested in basic yet translational immunology? The Hart lab might be a good fit.
We are seeking a strong post-doctoral candidate to join the Hart lab team.
The Hart lab has recently been fully funded by two NIH grants (R01 and R21). Big picture; we want to understand what antibodies are DOING in infectious disease to protect or hinder productive immune responses. Dogma suggests the main function of antibodies is to neutralize or block pathogens, however recent data from Dr. Hart and others suggests alternative mechanisms via Fc receptors may actually play a substantial role in clearing infectious agents (Hart et al., JEM 2019). These findings have direct translational impact on what proteins vaccinologists choose to immunize against (For example merozoite vs. infected RBC surface targets for malaria or Spike subunit 1 vs subunit 2 for Sars-Cov-2 in coronavirus). The Hart lab utilizes human cohort studies for direct translation of results and mouse experiments to drill down on mechanisms. With this bi-layered approach, the goal is to generate higher impact manuscripts.
There are currently projects looking at the function of antibodies, natural killer cells, and other Fc receptor+ innate cells in malaria, HIV and/or coronavirus infection. Multiple projects have preliminary positive data and are ready for someone to take the reigns and drive them forward to publication.
The Hart lab specializes in multi-color flow cytometry assays, CRISPR technology, human cohorts studies, Fc receptor mouse models, humanized mouse models, and malaria parasitology. We have a positive training environment where Dr. Hart can directly train people in certain areas and also give independence to pursue projects.
Training environment: Dr. Hart is a member of the Center for Immunology and Natural Killer cell interest group, and has collaborations with world renowned malaria scientists. This will provide additional support for a post-doctoral trainee to flourish.
Job Duties: 100%- Project development and completion There are multiple projects in the lab that need a passionate focused attention to build upon preliminary data and complete. We have both projects that are straight forward for publication and others that require more data, insight, and development with a potential for high impact. This balance will assure a productive post-doctoral experience. The focus of the post-doc's time will be on mostly obtaining data and analyzing it, then eventually pulling the data together, writing up the manuscript, presenting the data and national and international meetings (and repeat). The Hart lab has its own 13 color flow cytometer, and access to a 28 color BD flow cytometer. The post-doc will also be given the opportunity to write and apply for national fellowships. The Center for Immunology is a highly renowned center and provides a supplement to the training of the post-doc. The overall goal of the Hart lab is to train post-docs to the highest standard by getting multiple manuscripts, grants, and awards and have the writing and presentational skills to obtain whatever kind of job they want when they finish.
Required Qualifications: Must be documented in application materials
Ph.D. or MD is required.
Preferred Qualifications: Basic immunology background Cellular techniques and analysis (Flow cytometry and FlowJo) Protein generation and purification Plasmodium parasitology Monoclonal antibody production
Writing skills Presentation skills Ability to work well with diverse people and communicate effectively. Interest in basic yet translational human immunology. Interest in working in east African laboratory (for short periods) to obtain fresh sample data.
Internal Number: 336461
About University of Minnesota, Twin Cities
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.