Restrictions: Limited to a period of three years up to five, depending on training needs. The individual may be immediately post-degree or returning for additional training, updating, and retooling. Limited to fields for which post-degree training is necessary for career entry. Post-doctoral associates cannot be appointed on sponsored institutional training grants, sponsored individual fellowship or training awards. Post-doctoral associates are University of Minnesota employees. They are receiving additional training while also performing services for the University, for which they are compensated.
Note: These are not positions to which permanent residency can be granted for international appointees.
About the Job: A new U54 (Program Project) grant has been awarded by NCI for the national Moonshot Initiative in Mechanisms of Drug Resistance and Sensitivity in Cancer (DRSC). This is part of a national program that was awarded to the University of Minnesota in partnership with Mayo Clinic for the project: “Overcoming Drug Resistance in Multiple Myeloma". The central hypothesis we are addressing is that rational therapeutic development in MM should be based on an understanding of the underlying genetics and biology of the tumor that identify sensitivity and resistance to current and future drugs. The person hired will be responsible for leading efforts to collect genetic data and analyze for predictions of drug response, resistance and toxicities.
Job Duties: (20%) Develop a high throughput drug screening platform for myeloma cell lines representing the wide diversity of MM biology; and use this platform to screen primary patient tumor cells for most effective responses, including combination therapies.
(20%) Develop a comprehensive mutational and germline variation panel that will be correlated to drug responses in vitro and in vivo, as well as toxicities.
(20%) Identify tumor sub-populations that may contribute to emerging resistance.
(20%) Develop genetic predictions of adverse responses to therapeutics.
(10%) Identify the mechanism of response and resistance for two of the most common therapeutics used in MM treatment: IMiDS and proteasome inhibitors.
(10%) Develop genetic and immunophenotypic signatures that effectively predict tumor response, resistance, and patient toxicities.
The University of Minnesota offers a comprehensive benefits package including:
Competitive wages, paid holidays, vacation and sick leave
Low cost medical, dental, and pharmacy plans
Health care and dependent daycare flexible spending accounts
Excellent retirement plans with employer match
Disability and employer paid life insurance
Wellbeing program with reduced insurance premiums
Tuition reimbursement opportunities covering 75%-100% of eligible tuition
Student loan forgiveness opportunity
Opportunities for growth and promotion
Employee Assistance Program
As a Postdoctoral Associate at the University of Minnesota, you are considered to be in an academic professional position governed by academic policies. The link to governing policies is at http://policy.umn.edu/sites/policy.umn.edu/files/appendix/postdocappoint_appa.pdf
Required Qualifications: Ph.D. in a biologic science. Experience in genomic technologies, informatics and computational approaches.
Preferred Qualifications: Leadership experience; grant writing experience; evidence of productivity (publications, grants); experience in laboratory research in hematologic malignancies.
Internal Number: 338531
About University of Minnesota, Twin Cities
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.