Research - Laboratory/Non-Laboratory, Staff/Administrative
Summary of Position: This postdoctoral position is for a Neuroscientist to work on the NIH-funded projects to study the pathogenesis and therapeutics of Alzheimer’s disease using genetically modified mouse models and human patient materials. The postdoctoral fellow will use molecular, cellular, electrophysiological, and behavioral approaches to investigate the role of HDL/apolipoproteins, protein prenylation, and related signaling pathways in Alzheimer’s disease. Principal Duties and Responsibilities:
25% Establish and maintain genetically modified mouse models: Generate and/or use genetically modified mouse models, expand and maintain the mouse colonies. Design and perform genetic and pharmacological treatment experiments in animal models, followed by functional analysis to study the effects on the progression of Alzheimer’s disease and related conditions.
25% Neurobehavioral and electrophysiological studies: Design and perform neurobehavioral tests and electrophysiological studies in experimental animals to investigate the effect of genetic and pharmacological manipulation on cognitive/synaptic functions. Perform data analysis, interpretation, presentation, and manuscript preparation.
35% Cellular and molecular studies: Design and perform biochemical/molecular analyses, including (but not limited to) ELISA, immunohistochemical, histochemical, enzymatic, proteomic/transcriptomic analyses, etc to better understand the cellular and molecular mechanisms underlying the progression of Alzheimer’s disease and related conditions. Perform data analysis, interpretation, presentation, and manuscript preparation.
5% Lab maintenance: Ensure lab instruments are functioning properly, lab supplies/reagents are in good conditions, solutions are prepared properly, and lab storage and working areas are clean and organized. Keep meticulously detailed records of all experiments and procedures. Prepared laboratory standard operating procedures for experiments as needed.
5% Training: Train undergraduates, graduate students, and/or other researchers to perform relevant experiments.
5% Collaborative research: Interact with collaborators and coordinate collaborative research as needed.
Supervision: Train undergraduates, graduate students, and/or other researchers to perform relevant experiments.
Required Qualifications: Candidates should possess a Ph.D. degree with a strong background and interest in neuroscience and/or neurodegenerative disease research.
Preferred Qualifications: Highly self-motivated and career-oriented scientists with experience in rodent brain slice/in vivo electrophysiology, primary neural cell culture, human iPSC culture, confocal microscopy, and/or transcriptome analysis are desirable.
Internal Number: 325025
About University of Minnesota, Twin Cities
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.